SPATA 2 – Keeping the TNF signal short and sweet

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SPATA2 - Keeping the TNF signal short and sweet.

In this issue of The EMBO Journal, a multilayered global proteome resource, which comprehensively covers TNF-induced phosphorylation and ubiquitination events as well as receptor interactions, has led to identification of SPATA2 as a novel player that contributes to TNF signalling by interacting with the LUBAC ubiquitin ligase and the CYLD deubiquitylase. Loss of SPATA2 augments transcriptional...

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ژورنال

عنوان ژورنال: The EMBO Journal

سال: 2016

ISSN: 0261-4189,1460-2075

DOI: 10.15252/embj.201695061